Try the xlrd library. From what I can see from your comment, something like the snippet below might do the trick. I'm assuming here that...
I see two answers with good qualities, each with a small flaw, so I will give my take on it: Try os.path.exists, and consider os.makedirs...
We are writing Python code using Vim, and every time we want to run my code, we type this inside Vim
Installation of pysftp in debian 9 and Ubuntu
How to change the Jupyter Lab start-up folder